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Jednom za sva vremena - l-carnitin

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ThornOfFaith View Drop Down
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    Posted: 28 Veljaca 2009 at 22:49
"To be used for energy, the FFA has to be transported into the mitochondria by an enzyme called carnitine palmityl transferase (CPT). Incidentally, this is the idea behind carnitine supplements; by increasing levels of CPT, you get more fat burning. While this is great in theory, it doesn't really work in practice (if it does, the doses needed are absurdly high and expensive)."

Lyle McDonald, The Ultimate Diet 2.0
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Iluvatar Quote  Post ReplyReply Direct Link To This Post Posted: 01 Ožujak 2009 at 21:23
Da malo poduprem kolegu da bude još jansije ;) tj za one zahtjevnije ;)

sa Pubmeda:

However, the following arguments derived from established scientific observations may be forwarded: (i) carnitine supplementation neither enhances FA oxidation in vivo or spares glycogen or postpones fatigue during exercise. Carnitine supplementation does not unequivocally improve performance of athletes; (ii) carnitine supplementation does not reduce body fat or help to lose weight (iii) in vivo pyruvate dehydrogenase complex (PDC) is fully active already after a few seconds of intense exercise. Carnitine supplementation induces no further activation of PDC in vivo; (iv) despite an increased acetyl-CoA/free CoA ratio, PDC is not depressed during exercise in vivo and therefore supplementary carnitine has no effect on lactate accumulation; (v) carnitine supplementation per se does not affect the maximal oxygen uptake (VO2max); (vi) during exercise there is a redistribution of free carnitine and acylcarnitines in the muscle but there is no loss of total carnitine. Athletes are not at risk for carnitine deficiency and do not have an increased need for carnitine. Although there are some theoretical points favouring potential ergogenic effects of carnitine supplementation, there is currently no scientific basis for healthy individuals or athletes to use carnitine supplementation to improve exercise performance.

by:
Department of Clinical Chemistry, Turku University Hospital, Finland.

Pa kome znanstvena studija nije dovoljna... neka slobodno potraži drugo mjesto gdje ce tražiti pomoc
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Post Options Post Options   Thanks (0) Thanks(0)   Quote ThornOfFaith Quote  Post ReplyReply Direct Link To This Post Posted: 01 Ožujak 2009 at 22:19
Nije loše illy

Iako bi i ovdje mogao doci neki skeptik i reci (cak i naci studiju) kako je sasvim suprotno i dati neki dokaz.

McDonald (kojeg još više cijenim nakon procitane knjige ud 2.0) sasvim realno kaže kako je karnitin teoretski efikasan ali da u stvarnosti nema koristi od dodatne suplementacije jer karnitina svi imamo dovoljno, a tamo gdje je najveci problem - mobilizacija masti, pomaže i najobicnija crna kava.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Iluvatar Quote  Post ReplyReply Direct Link To This Post Posted: 01 Ožujak 2009 at 23:04
evo ti prvi dio studije..

koji govori upravo o toj efikasnosti u teoriji

Carnitine plays a central role in fatty acid (FA) metabolism. It transports long-chain fatty acids into mitochondria for beta-oxidation. Carnitine also modulates the metabolism of coenzyme-A (CoA). It is not surprising that the use of supplementary carnitine to improve physical performance has become widespread in recent years, although there is no unequivocal support to this practice.

nastavak je u prvom postu i zapocinje sa However..   
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